Jingjing Yang
Associate Professor
Secondary Appointment, Biostatistics and Bioinformatics
After completing my Ph.D. in statistics at Rice University, I have been studying Statistical Genetics since my Postdoctoral training at the Biostatistics Department of the University of Michigan at Ann Arbor. I am interested in developing statistical methods and tools to integrate multi-omics data for studying complex human diseases, such as Alzheimer's Disease, mobility disability, and Parkinson's disease. We utilize Bayesian statistical methods, machine learning, and deep learning methods with efficient computational algorithms for studying multi-omics data. My lab has also been working on analyzing next-generation sequence data (bulk seq and single nucleus seq) and biomedical signal/image data. The programming languages we use include R, Python, C++, and Perl. The computation environments we use are Linux/Unix computation clusters with shell/bash scripts and Amazon Web Services. The current research topics include integrating molecular genomics data and functional annotations with GWAS summary data for mapping risk genes of complex diseases, deriving risk prediction models for Alzheimer's disease, and sequencing data analysis.
Contact Information
615 Michael Street Suite 305K
Atlanta , GA 30322
Phone: 404-727-3481
Email: Jingjing.yang@emory.edu
Areas of Interest
- Bayesian Analysis
- Genetic Association Studies
- Genetic Epidemiology
- Genomics
- Longitudinal Analysis
- Machine Learning
Education
- Ph.D. 2014, Rice University
- M.S. 2009, Clemson University
- B.S. 2007, Jilin University
Affiliations & Activities
Dr. Yang is affiliated with the Department of Biostatistics and Bioinformatics School of Public Health (secondary appointment) and the Department of Human Genetics School of Medicine (home department). Dr. Yang takes master's and Ph.D. students from the GMB and PBEE Ph.D. programs under the Graduate Division of Biological and Biomedical Science, http://www.biomed.emory.edu/, as well as the Department of Biostatistics and Bioinformatics, School of Public Health. More information about the Yang lab is available from https://yanglab-emory.github.io/.
Publications
- Randy L Parrish, Aron S Buchman, Shinya Tasaki, Yanling Wang, Denis Avey, Jishu Xu, Philip L De Jager, David A Bennett, Michael P Epstein, Jingjing Yang, 2024, SR-TWAS: leveraging multiple reference panels to improve transcriptome-wide association study power by ensemble machine learning, Nature Communications, 15, 6646
- Dai Q, Zhou G, Zhao H, Võsa U, Franke L, Battle A, Teumer A, Lehtimäki T, Raitakari OT, Esko T, Epstein MP, Yang J. , 2023, OTTERS: a powerful TWAS framework leveraging summary-level reference data, Nat Commun. , 14, 1271
- Chen J, Wang L, De Jager PL, Bennett DA, Buchman AS, Yang J. , 2022, A scalable Bayesian functional GWAS method accounting for multivariate quantitative functional annotations with applications for studying Alzheimer disease, HGG Adv. , 3, 100143
- Parrish RL, Gibson GC, Epstein MP, Yang J. , 2022, TIGAR-V2: Efficient TWAS tool with nonparametric Bayesian eQTL weights of 49 tissue types from GTEx V8, HGG Advances, 3, 100068
- Tang S, Buchman AS, De Jager PL, Bennett DA, Epstein MP, Yang J. , 2021, Novel Variance-Component TWAS method for studying complex human diseases with applications to Alzheimer's dementia, PLOS Genetics, 17, e1009482
- Justin M Luningham, Junyu Chen, Shizhen Tang, Philip L De Jager, David A Bennett, Aron S Buchman, Jingjing Yang, 2020, Bayesian Genome-wide TWAS method to leverage both cis-and trans-eQTL information through summary statistics, American Journal of Human Genetics, 107, 714-726
- Sini Nagpal, Xiaoran Meng, Michael P Epstein, Lam C Tsoi, Matthew Patrick, Greg Gibson, Philip L De Jager, David A Bennett, Aliza P Wingo, Thomas S Wingo, Jingjing Yang, 2019, TIGAR: An Improved Bayesian Tool for Transcriptomic Data Imputation Enhances Gene Mapping of Complex Traits, American Journal of Human Genetics, 105, 258-266