Data Dictionary

Throughout the history of the registry, several questionnaires and blood samples have been collected. We have included a partial list of the questionnaire datasets available. If you have additional questions or would like clarification about these data, please contact us.

Below is a table of demographic characteristics, exposures, and health outcomes that have been measured throughout the PBB registry. Each column represents a different questionnaire, and the header indicates the years of data collection and the number of participants. Under each questionnaire, an X will appear if that questionnaire contains that topic.

Note: How to filter and reset table
  • To filter by topic, please click on the item and click either Keep Only or Exclude.
  • To reset your selections and the table, please click the |← button below the table.

Publication/Analysis

Below is a partial list of published studies conducted utilizing data collected from the Michigan PBB Registry.

 

2020:

Serum concentrations of polybrominated biphenyls (PBBs), polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) in the Michigan PBB Registry 40 years after the PBB contamination incident (2020) Environment International, Exposure levels

Hormonal Profiles of Menstrual Bleeding Patterns During the Luteal-Follicular Transition (2020) Journal of Clinical Endocrinology and Metabolism, Menstrual Function

Detrimental effects of flame retardant, PBB153, exposure on sperm and future generations (2020) Scientific Reports, Male Reproductive Effects

Examining Reproductive Health outcomes in females exposed to polychlorinated Biphenyl and polybrominated Biphenyl (2020) Scientific Reports, Pregnancy/birth outcomes

Sex-specific DNA methylation differences in people exposed to polybrominated biphenyl (2020) Epigenomics, Epigenetics

Endometriosis, endocrine disrupters, and epigenetics: an investigation into the complex interplay in women with polybrominated biphenyl exposure and endometriosis (2020) Journal of Asisted Reproduction and Genetics, Endometriosis

2019:

Thyroid hormone levels associate with exposure to polychlorinated biphenyls and polybrominated biphenyls in adults exposed as children (2019) Environmental Health Perspectives, Thyroid Function

Polybrominated Biphenyl Exposure and Menstrual Cycle Function (2019) Epidemiology, Menstrual Function

Exposure to polybrominated biphenyl (PBB) associates with genome-wide DNA methylation differences in peripheral blood (2019) Epigenetics, Epigenetics

Exposure to polybrominated biphenyl and stochastic epigenetic mutations: application of a novel epigenetic approach to environmental exposure in the Michigan polybrominated biphenyl registry (2019) Epigenetics, Epigenetics

Environmental exposure to polybrominated biphenyl (PBB) associates with an increased rate of biological aging (2019) Aging, Epigenetics

Multigenerational metabolic profiling in the Michigan PBB registry (2019) Environmental Research, Metabolomics

2018:

Thyroid hormones and menstrual cycle function in a longitudinal cohort of premenopausal women (2018) Paediatric and Perinatal Epidemiology, Thyroid Function

Intergenerational effects of endocrine-disrupting compounds: a review of the Michigan polybrominated biphenyl registry (2018) Epigenomics, Epigenetics

2017:

Serum Polybrominated Biphenyls (PBBs) and Polychlorinated Biphenyls (PCBs) and Thyroid Function among Michigan Adults Several Decades after the 1973–1974 PBB Contamination of Livestock Feed (2017) Environmental Health Perspectives, Thyroid Function

2016:

Breast cancer among women in Michigan following exposure to brominated flame retardants (2016) Occupational and Environmental Medicine, Cancer

Exposure to PBB-153 and Digit Ratio (2016) Early Human Development, Pregnancy/birth outcomes

2015:

Maternal exposure to brominated flame retardants and infant Apgar scores (2015) Chemosphere, Pregnancy/birth outcomes

2011:

Incidence of thyroid disease following exposure to polybrominated biphenyls and polychlorinated biphenyls, Michigan, 1974–2006 (2011) Chemosphere, Thyroid Function

Dietary exposure to brominated flame retardants and abnormal Pap test results (2011) Journal of Women's Health, Cancer

Reproductive outcomes among women exposed to a brominated flame retardant in utero (2011) Archives of Environmental and Occupational Health, Reproductive outcomes

2009:

A cohort study of the association between secondary sex ratio and parental exposure to polybrominated biphenyl (PBB) and polychlorinated biphenyl (PCB) (2009) Environmental Health, Secondary sex ratio

In utero exposure to a brominated flame retardant and male growth and development (2009) International Journal of Child and Adolescent Health, Genitourinary (GU) conditions, Growth and development

Assessing inter-generational transfer of a brominated flame retardant (2009) Journal of Environmental Monitoring, Other

2007:

Endometriosis among women exposed to polybrominated biphenyls (2007) Annals of Epidemiology, Endometriosis

Maternal exposure to polybrominated and polychlorinated biphenyls: infant birth weight and gestational age (2007) Chemosphere, Pregnancy/birth outcomes

Risk of Spontaneous Abortion among Women Exposed to Polybrominated Biphenyls (2007) Environmental Research, Pregnancy/birth outcomes

The influence of age at exposure to PBBs on birth outcomes (2007) Environmental Research, Pregnancy/birth outcomes

2006:

Polybrominated biphenyls, polychlorinated biphenyls, body weight, and incidence of adult-onset diabetes mellitus (2006) Epidemiology, Diabetes

2005:

Menstrual function among women exposed to polybrominated biphenyls: a follow-up prevalence study (2005) Environmental Health, Menstrual Function

2004:

Time to menopause in relation to PBBs, PCBs, and smoking (2004) Maturitas, Time to Menopause

2003:

Polybrominated biphenyl exposure and benign breast disease in a cohort of US women (2003) Annals of Epidemiology, Cancer

2002:

Growth in girls exposed in utero and postnatally to polybrominated biphenyls and polychlorinated biphenyls (2002) Epidemiology, Growth and development

1990:

The Caffeine Breath Test and Caffeine Urinary Metabolite Ratios in the Michigan Cohort Exposed to Polybrominated Biphenyls: A Preliminary Study (1990) Environmental Health Perspectives, Liver Function

1987:

Immunotoxicology: environmental contamination by polybrominated biphenyls and immune dysfunction among residents of the State of Michigan (1987) Cancer Detection and Prevention, Immunological

1984:

The Transfer of Polychlorinated Biphenyls (PCBs) and Polybrominated Biphenyls (PBBs) Across the Human Placenta and into Maternal Milk (1984) American Journal of Public Health, Exposure levels

Mortality of workers potentially exposed to organic and inorganic brominated chemicals, DBCP, TRIS, PBB, and DDT (1984) British Journal of Industrial Medicine, Overall Mortality

Polybrominated Biphenyls and Fetal Mortality in Michigan (1984) American Journal of Public Health, Birth Outcomes

1983:

Partitioning of polybrominated biphenyls (PBBs) in serum, adipose tissue, breast milk, placenta, cord blood, biliary fluid, and feces (1983) Archives of Environmental Health, Exposure levels

Effect of Polybrominated Biphenyls (PBB) on Developmental Abilities in Young Children (1983) American Journal of Public Health, Neurological

Developmental Abilities of Children Exposed to Polybrominated Biphenyls (PBB) (1983) American Journal of Public Health, Neurological

1982:

Cutaneous effects of exposure to polybrominated biphenyls (PBBs): the Michigan PBB incident (1982) Environmental Research, Dermatological

1981:

Memory performance of chemical workers exposed to polybrominated biphenyls (1981) Science, Neurological

The Human Health Effects of Exposure to Polybrominated Biphenyls (1981) Toxicology and Applied Pharmacology, Various Symptoms

1980:

Hypothyroidism in workers exposed to polybrominated biphenyls (1980) The New England Journal of Medicine, Thyroid Function

Pediatric Aspects of the Michigan Polybrominated Biphenyl Contamination (1980) Environmental Research, Various Symptoms

1979:

Neuropsychiatric Findings in Patients Exposed to Polybrominated Biphenyls (1979) Annals of the New York Academy of the Sciences, Liver Function, Neurological

Impaired Immune Function and Identification of Polybrominated Biphenyls (PBB) in blood Compartments of Exposed Michigan Dairy Farmers and Chemical Workers (1979) Drug and Chemical Toxicology, Immunological

Immunologic dysfunction among PBB-exposed Michigan dairy farmers (1979) Annals of the New York Academy of the Sciences, Immunological

Cohort Study of Michigan Residents Exposed to Polybrominated Biphenyls: Epidemiologic and Immunologic Findings (1979) Annals of the New York Academy of the Sciences, Immunological, Diabetes, Cancer

Lymphocyte function in humans exposed to polybrominated biphenyls (1979) Journal of the Reticuloendothelial Society, Immunological

Spermatogenesis in Men Exposed to Polybrominated Biphenyls (PBB) (1979) Fertility and Sterility, Male Reproductive Effects

Exposure to Polybrominated Biphenyl: Some Effects on Personality and Cognitive Functioning (1979) Journal of the American Medical Association, Neurological

The neurotoxicity of polybrominated biphenyls: results of a medical field survey (1979) Annals of the New York Academy of the Sciences, Neurological

Symptoms and clinical abnormalities following ingestion of polybrominated-biphenyl-contaminated food products (1979) Annals of the New York Academy of the Sciences, Various Symptoms

1978:

Breast-milk Monitoring to Measure Michigan’s Contamination with Polybrominated Biphenyls (1978) The Lancet, Exposure levels

Relation of DDE and PBB Serum Levels in Farm Residents, Consumers, and Michigan Chemical Corporation Employees (1978) Environmental Health Perspectives, Exposure levels

Liver Function Tests among Michigan and Wisconsin Dairy Farmers (1978) Environmental Health Perspectives, Liver Function

Investigation of the Health Status of Michigan Chemical Corporation Employees (1978) Environmental Health Perspectives, Liver Function

Comparison of Findings among Residents on Michigan Dairy Farms and Consumers of Produce Purchased from These Farms (1978) Environmental Health Perspectives, Liver Function, Dermatological, Neurological

Unanticipated Prevalence of Symptoms Among Dairy Farmers in Michigan and Wisconsin (1978) Environmental Health Perspectives, Dermatological, Neurological, Thyroid Function, Diabetes

Investigation of the Health Status of Michigan Chemical Corporation Employees (1978) Environmental Health Perspectives, Dermatological

Lymphocyte Function of Michigan Dairy Farmers Exposed to Polybrominated Biphenyls (1978) Science, Immunological

Comparative Neurobehavioral Study of a Polybrominated Biphenyl-Exposed Population in Michigan and a Nonexposed Group in Wisconsin (1978) Environmental Health Perspectives, Neurological

Carcinoembryonic Antigen (CEA) Plasma Levels in Michigan and Wisconsin Dairy Farmers (1978) Environmental Health Perspectives, Cancer

Pediatric Health Aspects of PBBs (1978) Environmental Health Perspectives, Various Symptoms

If you don't see the data you want, please request data here.
If you have questions, please contact us.